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Comprehensive assessment of cognitive function in adults with moderate and severe sickle cell disease.. Leticia Candra 3 , Caterina Rosano 1 , Enrico M Novelli 3 Affiliations 1 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 2 Department of Psychiatry.

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Cognitive impairment (CI) is a serious complication of sickle cell disease (SCD) and can cause significant functional and social limitations. To date, there are only a few studies characterizing CI in adults with SCD.

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. Specifically, we tested whether rare driver mutations predicted by CanDrA are enriched in the COSMIC census cancer genes.

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The few T cells that develop from progenitors expressing TCF-1 lacking L1 exhibit lineage infidelity distinct from the lineage diversion of TCF-1-deficient cells. Mechanistically, L1 is required.

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CanDrA is a machine learning program that predicts cancer-type specific driver missense mutations based on 96 structural, evolutionary and gene features computed by over 10 other functional prediction algorithms. CanDrA training set is collected based on mining COSMIC database.

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Candra: Gambit #1 (December 1993) A member of the Externals, Candra is a mutant with powerful telekinetic abilities and immortality. Candra is most often associated with the Assassins and Thieves Guilds where she is known as the Benefactress, bestowing great powers to those who serve her. She also has a history with Storm, who had stolen the.

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Here, we present a cancer driver annotation (CanDrA) tool that predicts missense driver mutations based on a set of 95 structural and evolutionary features computed by over 10 functional prediction algorithms such as CHASM, SIFT, and MutationAssessor.

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SCD patients were recruited from the University of Pittsburgh Medical Center Adult Sickle Cell Program outpatient clinic between 2016 and 2019. All patients with HbSS and HbS/β 0 thalassemia (severe genotypes) or HbSC and HbS/β + thalassemia (moderate genotypes) 18 years or older (N=161) were informed about the study during a routine clinic.

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Red Death Other Aliases: Benefactress, Candra of the Floating Spires Affiliation and Relationships Physical Characteristics Origin and Living Status Personal Information Creators and Appearances Creators Howard Mackie, Lee Weeks First

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Adult Sickle Cell Program. Falk Medical Building 3601 Fifth Avenue 6th Floor, Suite 6A Pittsburgh, PA 15213 T 412-864-2661 F 412-864-2663. Christopher Quammen, PA-C.. Leticia Candra Charles Jonassaint Jude Jonassaint. Manzoor Mohideen Emily Nardo. Benign Hematology. About the Section of Benign Hematology; Rare Hematological Disease Program;

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Mutations might tell cells to grow and divide uncontrollably and to continue living when normal cells would die. If this happens, the accumulating abnormal cells can form a tumor. Cells can break away and spread (metastasize) to other parts of the body. Risk factors. Factors that can increase the risk of sarcoma include: Inherited syndromes.

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CanDrA is a computer program that predicts cancer-type specific driver missense mutations CliP Clonal structure identification through penalizing pairwise differences DeMixT Cell type-specific deconvolution of heterogeneous tumor samples with two or three components using expression data from RNAseq or microarray platforms drugBase